OncoMAR™’s dramatic effects are the result of at least six different mechanisms of action. The most unique mechanism is its ability to selectively inhibit non-oxidative glucose metabolism in cells that typically use glucose at a 10-50 times higher rate than normal cells.[1] The formula does not have any effect upon the glucose metabolism of healthy cells unless it is given at 50 times the recommended dose.[2]

VERY IMPORTANT

THIS PRODUCT MUST BE SHIPPED ON ICE IN AN INSULATED BOX.  IT IS PERISHABLE AND HEAT LIABLE.  DO NOT ACCEPT THIS PRODUCT IF IT IS NOT SHIPPED THAT WAY. THIS PRODUCT MUST BE SHIPPED 2ND DAY AIR IF ORDERED OUTSIDE OF FLORIDA.  SHIPPING IS FREE.  

Two other mechanisms are its actions of inhibition of PARP (poly-ADP-ribose), an enzyme needed to repair DNA breaks,[3] and enhancement of Caspase-3, an enzyme that initiates apoptosis.[4]

The Research also demonstrates OncoMAR™ restores normal metabolic pathways of healthy cells and increases production of their related RNA and DNA, while reducing synthesis of these nucleic acids in abnormal cells.[5] 
 

Furthermore, OncoMAR™ assists the NK cells in identifying targets for attack by suppressing the abnormal cells’ ability to generate a surface molecule (“MHC-1”) used by these cells to mask themselves from the immune system.[6,7]

OncoMAR™ optimizes the functioning of macrophages, T-cells and B-cells. It normalizes the imbalance of cellular and humoral (Th1/Th2) immune function that results from age and stress.

The formula also inhibits COX-1 and COX-2 enzymes  [8,9,10,11]

Dr. Albert Szent-Gyorgyi, a 1937 recipient of the Nobel Prize in Medicine initiated development of this formula. His theory regarding the stabilization of cell metabolism with DMBQ (2,6-dimethoxy-p-benzoquinone), a naturally occurring molecule, inspired Dr. Maté Hidvegi of Hungary to develop and patent the formula in 1989.[12]

OncoMAR™ is FDA GRAS-certified. Each single-serving packet of capsules/powder of OncoMAR™ contain the same dose (5.5g) of the identical Avemar consumed and well-tolerated in numerous clinical trials. OncoMAR™ is used adjunctively to enhance standard protocols, or can be used by almost anyone as a stand-alone supplement for wellbeing.

Hematological values remained within normal range after one, three, and five years of formula use.

Most people who use OncoMAR™ daily have reported within three weeks they notice increased energy, improved appetite and a generally improved quality of life. However, depending upon the individual case, results may vary.

ONCOMAR

• Supports Cell Metabolic Regulation

• Supports Immune System Modulation

• Maintains Healthy Cellular and Humoral (Th1/Th2) Immune Balance

• Promotes Optimal Natural Killer (NK) Cell Targeting Ability

• Promotes Coordinated Response of Macrophages, B-Cells and T-Cells

OncoMAR™ contains a proprietary nutritional ingredient, Avemar. The active ingredient is produced by

fermentation of wheat germ by baker's yeast and is standardized for the compound DMBQ

(2,6-di-methoxy-substituted benzoquinones).

More than 100 animal and human studies, resulting in more than 30 articles in peer-reviewed medical journals have demonstrated efficacy, mechanism of action and safety.

* Percent Daily Values are based on a 2,000 calorie diet.

Serving Size: 1 Package 5.53 g (0.2 oz.)

Servings Per Container: 30

Supplement Facts

Ingredients:

natural orange flavor.

Freeze-dried fermented wheat germ extract, stevia Reb-A extract,
Allergen Statement:

* Percent Daily Values are based on a 2,000 calorie diet.

Serving Size: 1 Packet (8 capsules)

Servings Per Container: 30

This product contains wheat and yeast ingredients.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Cautions

The following individuals should not use OncoMAR™: pregnant or nursing women, recent organ or tissue recipients, GI bleeding from ulcers, gluten-sensitive enteropathies (celiac sprue), or hypersensitivity to gluten, wheat germ or any component(s) or ingredient(s) in OncoMAR™. Discontinue 2 days prior to barium X-rays and resume 2 days after completion of the exam.

Dosing

Take one packet of OncoMAR™ capsules (8 capsules) daily. For individuals

weighing >200 lbs, take two packets of capsules daily. It is best to consume

OncoMAR™ one hour before or after a meal, and two hours before or after

any drugs or other dietary supplements. Consult with a practitioner for use in

children, with other supplements, and/or for alternative dosing instructions.

If loose stools occur, take 4 capsules in the morning and other 4 in the late

afternoon. For long term results, use for at least six months. Safety has been

demonstrated with daily use over several years.

Dosing

Powder

As a dietary supplement for adults, use 1 OncoMAR™ packet (5.53g,

providing 5.5g Avemar

contents of OncoMAR™ packet to 4 oz. (120mL) of cold water or juice, mix

well and drink within 30 minutes. (For best results, mix by shaking with ice.)

To maximize absorption, consume OncoMAR™ approximately 1 hour before

or after food, and 2 hours before or after taking any drugs or dietary supplements.

REFERENCES

1. Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells.

2001;23(2):141-7 [PMID: 11484916]

2. Heimbach JT, et al. Safety studies regarding a standardized extract of fermented wheat germ.

3. Comin-Anduix B, et al. Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly (ADP-ribose) polymerase

activation in Jurkat T-cell leukemia tumor cells.

4. Farkas E. [Fermented wheat germ extract in the supportive therapy of colorectal cancer]

5. Boros LG, et al. Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells.
Pancreas AugInt J Toxicol. 2007 May-Jun;26(3):253-9 [PMID: 17564907]J Biol Chem 277: 46408-46414, 2002. [PMID: 12351627]Orv Hetil. 2005 Sep 11;146(37):1925-31 [PMID: 16255377] Pancreas

6. Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.. 2001 Aug;23(2):141-7.Int J Oncol
2002;20: 563-570

7. Lopez-Botet M, Bellon T. Natural killer cell activation and inhibition by receptors for MHC class 1.

8. Studies of the effect of Avemar on tumor necrosis factor induced cytotoxicity and on TNF production of immune cells. Institute of Biochemistry, Biological Research

Center of the Hungarian Academy of Science. Szeged, 1999

9. Effects of Avemar on the early events of the immune response. Institute of Genetics, Biological Research Center of the Hungarian Academy of Science. Szeged,1999.

10. Effect of Avemar on macrophages and microvascular endothelial cells. Scientific meeting of the Albert Szent-Györgyi Medical and Pharmaceutical Center of the

Szeged University. Szeged, Hungary, 2000

11. Illmer, C. et al. Immunologic and biochemical effects of the fermented wheat germ extract Avemar.

12. Hidvegi, M., et al. Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental

Curr Opin. Immunol.1999 11:301-307Exp. Biol. Med. 2005 Feb;230:144-149 [PMID: 15673563]
capsules 

This product must be shipped on dry ice.  It is heat liable and perishable.